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MICROBIOLOGY

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5 DERNIERS ARTICLES
- Science:Revealed in the DNA of bacteria immune system discovery program on nucleic acid enzymes
- Biomaterials: inhibition of prion infection revealed new compounds
- Researchers reveal the key elements to resist virus infection MDA5
- CO2 sensing mechanism of micro-organisms where the fungi research has made new progress
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 CO2 sensing mechanism of micro-organisms where the fungi research has made new progress Alerter l'administrateur Recommander à un ami Lien de l'article 

Carbon dioxide is not only an important substrate for plant photosynthesis and cell respiration metabolic end products, is also an important signaling molecule involved in the regulation of a variety of biological processes. For example, carbon dioxide, blood-sucking female mosquitoes find suitable target signaling molecules, and high concentrations of carbon dioxide can promote animal germ cell maturation and swimming, and even affect the life of small animals (such as fruit flies and nematodes). Candida albicans is not only an important human pathogenic fungi, but also healthy people the body of common symbiotic bacteria. The human body, carbon dioxide concentration is much higher than the concentration of carbon dioxide in the air, studies show that carbon dioxide plays an important regulatory role in the pathogenic fungus Candida albicans morphological transformation and infection in the host process. High concentrations of carbon dioxide to promote the growth of mycelium and gray bacteria (opaque) formed so as to promote the colonization of Candida albicans in the body. Acknowledge the role of bacteria-host interactions and their long-term adaptive evolution results. Although the carbon dioxide play a very important role in biological evolution and cellular activities is still very limited understanding of the molecular mechanism of carbon dioxide sensors. Recently, Chinese Academy of Sciences Institute of Microbiology, Mycology State Key Laboratory of Huang Guanghua group study found that the transcription factor Flo8 play a key regulatory role in the induction of carbon dioxide the process of the Candida albicans. Flo8 contains a eukaryotic conserved LisH domains not only regulate the conversion of carbon dioxide-induced Candida albicans yeast - mycelium form ", and also controls the conversion between the" white fungus - gray fungus ". The study is the first time, Flo8 is required for the formation of carbon dioxide-induced mycelial growth and gray fungus. FLO8 gene overexpression enhanced the sensitivity of Candida albicans cells induced carbon dioxide.

  Aucun commentaire | Ecrire un nouveau commentaire Posté le 03-07-2012 à 09h39

 Researchers reveal the key elements to resist virus infection MDA5 Alerter l'administrateur Recommander à un ami Lien de l'article 

Recently, researchers from the University of Washington School of Medicine revealed during certain current virus infections, the key molecule MDA5 essential produce a sufficient amount of interferon against virus infection. The lack of MDA5 in a mouse model will force the immune system to find more effective defenders against infection, which will undoubtedly provide the virus an opportunity to allow the virus to establish a chronic long-term infection. The cavalry attack, as seen in the classic movie in the body in a timely time to overcome the infection is very critical. Interferon surge is early enough, the immune system will be limited in time and remove the virus, interferon increase relatively late, the body's defense capability will know what to do. Researchers Yaming Wang said that in the process of viral infection, we are in a different period of time a mouse model of interferon injection, you will find that this will reduce the spread of the virus and enhance the immune effector CD8 + cells. Plus interferon can also increase the effectiveness of anti-viral vaccines. The researchers' study results published in a recent international journal Cell Host & Microbe.

  Aucun commentaire | Ecrire un nouveau commentaire Posté le 04-07-2012 à 16h11

 Biomaterials: inhibition of prion infection revealed new compounds Alerter l'administrateur Recommander à un ami Lien de l'article 

Recently, researchers from the University of Alberta have discovered a new compound can inhibit the proliferation of abnormal protein in the brain, such abnormal proteins can raise a fatal neurodegenerative diseases of humans and animals.Neurodegenerative diseases such as human Creutzfeldt-Jakob disease and bovine, sheep brain disease can be attributed to dysfunctional proteins.

Researchers said such an abnormal protein in the brain, collapsed into a specific shape to perform its functions. But collapsed as soon as an error occurs, and as a result produces a prion, prion is a infectious protein.Details from Microbiology.
Researchers do not know why and how to fold proteins in the brain error, after the formation of prion, prion can damage the brain. Researchers West through research found that prions can be cleared of compounds, in laboratory studies, River party that for which it was designed when molecular compounds are used in infected cells, misfolding of proteins (prions) will be reduced, and there is time to study prion is not able to detect residues.Researchers say, making molecular drug through the stomach into the blood needs to be a certain size limit, so the design of novel compounds need to cross the blood-brain barrier into the central nervous system.
People can raise exposure to prion brain disorder with only rare grams Jakob or mad cow disease, the researchers said, developed into a very low proportion of BSE, only one out of 10,000. On the relevant results of the research were published in the International Journal of Biomaterials, the study supported by the Alberta prion research center.

  Aucun commentaire | Ecrire un nouveau commentaire Posté le 01-08-2012 à 10h20

 Science:Revealed in the DNA of bacteria immune system discovery program on nucleic acid enzymes Alerter l'administrateur Recommander à un ami Lien de l'article 

Recently, genetic engineers from Berkeley Lab studies have found edits of gene and genome group (editing genomes) new effective forms, the study for future new drug research and development and offer new proposals for the development of bioenergy, and it can be genetically modified micro-organisms, such as bacteria and fungi. Relevant research results published in the world's leading magazine on Science. Researchers found a double-stranded RNA structure primarily responsible for directing bacterial proteins to specific nucleotide sequences to clean external DNA sequences. Later researchers found in a study they programmed action might carry a single strand of RNA protein to purge some DNA sequences. Later researchers found in a study they programmed action might carry a single strand of RNA protein to purge some DNA sequences. Researchers Doudna says, we found that RNA was steering clear of double-unit DNA molecular mechanisms, and the key to this mechanism is precisely the acquired immune system bacterial. Research report noted that a programmed dual RNA-directed DNA nucleic acid enzymes of bacteria can adapt to the immune system, bacteria to survive, rely on an Adaptive immune system based on nucleic acids, this named CRISPR immune system to a genetic component-centric, CRISPR are Clustered Regularly Interspaced Short Palindromic Repeats the shorthand (clusters of regulation inverted repeat). CRISPRs and nucleic acid enzymes combined can take advantage of smaller specialized crRNA (CRISPR RNA derived from) as the targets to destroy viruses or other exogenous plasmid DNA. There are three different types of CRISPR/Cas immune system, researchers study II, which depends largely on the nucleic acid enzymes for targets to destroy foreign DNA. Researchers found in type II in the immune system, crRNA through trans activity of RNA base pairs to connect (tracr-RNA) to form two RNA structure. This binary structure of RNA molecules can guide Cas9 proteins at specific sites of introducing double-stranded DNA breaks. Cas9 tracrRNA:crRNA compounds can be combined in turn for guidance to join it to the DNA sequences to play a role. CRISPR system can be transplanted into bacteria in the different source, research data also reveals the CRISPR loci can be horizontally transferred between nature. Related research by the Howard Hughes medical support from, among others.

  Aucun commentaire | Ecrire un nouveau commentaire Posté le 15-08-2012 à 11h06



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  Blog créé le 29-06-2012 à 08h55 | Mis à jour le 15-08-2012 à 11h06 | Note : Pas de note